反应详情

To a solution of (S)-ethyl 2-(6-bromo-3-methyl-1-(trifluoromethylsulfonyloxy)naphthalen-2-yl)-2-hydroxyacetate (2 g, 4.26 mmol) in tert-butylacetate (30 mL) was added 70% perchloric acid (1.10 mL, 4.69 mmol). The reaction mixture was stirred for 2.5 hours and quenched with solid sodium bicarbonate and stirred for 45 minutes. Water and solid sodium bicarbonate were carefully added and stirred for another 15 minutes. The mixture was diluted with ethyl acetate, washed with saturated bicarbonate solution (2×), brine, dried (MgSO4), filtered, concentrated and purified by flash column chromatography (silica gel, 0 to 20% ethyl acetate/hexanes) to give the desired compound. 1H NMR (400 MHz, CDCl3) δ: 7.96 (s, 1H), 7.90 (d, J=10.2 Hz, 1H), 7.62 (d, J=9.2 Hz, 1H), 7.58 (s, 1H), 5.90 (s, 1H), 4.26-4.08 (m, 2H), 2.53 (s, 3H), 1.20 (s, 9H), 1.17 (t, J=7.1 Hz, 3H).

1. customquenched with solid sodium bicarbonate
2. stirringstirred for 45 minutes
3. additionWater and solid sodium bicarbonate were carefully added
4. stirringstirred for another 15 minutes
5. additionThe mixture was diluted with ethyl acetate
6. washwashed with saturated bicarbonate solution (2×), brine
7. dry with materialdried (MgSO4)
8. filtrationfiltered
9. concentrationconcentrated
10. custompurified by flash column chromatography (silica gel, 0 to 20% ethyl acetate/hexanes)