反应详情

温度

2.5 °C

To a mixture of morpholine-3-carboxylic acid (5 g, 38.1 mmol) and formic acid (46.6 g, 1.01 mol) cooled at 0-5° C. was added acetic anhydride (26.7 g, 262 mmol) dropwise. The resulting mixture was stirred at room temperature for 2 h. An excess of water was added while cooling the mixture. The resulting mixture was then concentrated under reduced pressure. The crude product 4-formyl-morpholine-3-carboxylic acid (6 g) was used in the next step without further purification. LC/MS (method 7): Rt=0.13 min; m/z=160.1 (M+H+).

1. temperaturewhile cooling the mixture
2. concentrationThe resulting mixture was then concentrated under reduced pressure
3. customThe crude product 4-formyl-morpholine-3-carboxylic acid (6 g) was used in the next step without further purification