反应详情

温度

25 °C

To a solution of (S)-2-methyl-propane-2-sulfinic acid ((R)-1-pyrimidin-2-yl-propyl)-amide (Comp. No. 14b) (2.6 g, 10.8 mmol) in methanol was added 4 M hydrogen chloride in dioxane (4.35 ml) and the mixture was stirred for 1 h at 25° C. Water (100 ml) was added and the aqueous phase was washed with methyl tert-butyl ether. The aqueous layer was freeze-dried to give 1.7 g (75%) of (R)-1-pyrimidin-2-yl-propylamine hydrochloride. LC/MS (method 5): Rt=0.68 min; m/z=138.15 (M+H+).

1. washthe aqueous phase was washed with methyl tert-butyl ether
2. customThe aqueous layer was freeze-dried