Isopropanol → HCID 71696589, compound

HRID 926399Notes

Reaction equation

HRID 926399 reaction equation
COC(C1CCCN1C(C1N2C(COCC2)=C(C(=O)N[C@@H](C2C=CC=CC=2)CC)C=1)=O)=O.[CH:33]([O:36][C:37]([CH:39]1[CH2:43]C[CH2:41][N:40]1[C:44]([C:46]1[N:54]2[C:49]([CH2:50][O:51][CH2:52][CH2:53]2)=[C:48]([C:55](=[O:66])[NH:56][C@@H:57]([C:60]2[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=2)[CH2:58][CH3:59])[CH:47]=1)=[O:45])=[O:38])(C)[CH3:34].C(O)(C)C>C(O)C>[CH2:33]([O:36][C:37](=[O:38])[C@@H:39]([N:40]([CH3:41])[C:44]([C:46]1[N:54]2[C:49]([CH2:50][O:51][CH2:52][CH2:53]2)=[C:48]([C:55](=[O:66])[NH:56][C@@H:57]([C:60]2[CH:61]=[CH:62][CH:63]=[CH:64][CH:65]=2)[CH2:58][CH3:59])[CH:47]=1)=[O:45])[CH3:43])[CH3:34]

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 1265144481-[8-((R)-1-Phenyl-propylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]-pyrrolidine-2-carboxylic acid methyl esterHCID 1317350171-[8-((R)-1-Phenyl-propylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]-pyrrolidine-2-carboxylic acid isopropyl ester

Product 1

HCID 71696589HCID 71696589, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The compound was obtained from comp. no. 16m as starting compound in analogy to the synthesis of comp. no. 16n. Isopropanol was replaced by ethanol to form the ester. LC/MS (method 4): Rt=1.24 min; m/z=454.27 (M+H+)

Workup

  1. customThe compound was obtained from comp
  2. customto the synthesis of comp

Sources & evidence

ORD record
ord-3425e88514154b2b9c11d9a78cb34839
Source dataset
uspto-grants-2016_03
Patent number
US09284333B2

Reaction notes

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