Methyl Palmitate → Methylether Palmitate

関与物質

反応条件

反応手順

Palmitic acid methyl ester (2.00 g; 7.40 mmol) was combined with poly(ethylene glycol) (PEG-12) monomethyl ether 550 (4.41 g; 7.40 mmol; 1.0 equiv) having an average molecular weight of 596 (available from Sigma-Aldrich Chemical Company) in a 40-milliliter vial equipped with a magnetic stir bar. Immobilized Candida antarctica lipase B immobilized on a porous fluoropolymer support as described in US published Patent Application 2012/0040395 was added to the flask in an amount of 0.13 grams, (2 wt % based on the total weight of starting materials). The mixture was stirred and heated to 65° C. and purged with a subsurface stream of nitrogen at a rate of 100 mL/min. After 24 hours a final sample was removed and analyzed by GC to determine conversion of methyl palmitate to palmitic acid methyl ester ethoxylate. Conversion was as follows: after 3 hours, 64.8%; after 6 hours, 80.8%, after 12 hours, 92.1%; and after 23 hours, 96.4%.

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