Acetone → (4-Chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(2,6-dimethylpyridin-3-yl)methanone

HRID 926460Notes

Reaction equation

HRID 926460 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH:12]([C:14]3[C:15]([CH3:21])=[N:16][C:17]([CH3:20])=[CH:18][CH:19]=3)[OH:13])[CH:10]=2)[N:5]=[C:4]([O:22][CH3:23])[C:3]=1[CH2:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=1.O1CCOCC1.[Al].CC(C)=O>O=[Mn]=O.CCCCCC>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([C:14]3[C:15]([CH3:21])=[N:16][C:17]([CH3:20])=[CH:18][CH:19]=3)=[O:13])[CH:10]=2)[N:5]=[C:4]([O:22][CH3:23])[C:3]=1[CH2:24][C:25]1[CH:26]=[CH:27][C:28]([C:31]([F:33])([F:32])[F:34])=[CH:29][CH:30]=1

Participants

7

Reactant 4

HCID 180AcetoneHCID 312751,4-DioxaneHCID 5359268AluminumHCID 86715629(4-Chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(2,6-dimethylpyridin-3-yl)methanol2×

Product 1

HCID 86715630(4-Chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(2,6-dimethylpyridin-3-yl)methanone

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 8058HexaneSolvent

Procedure

To a 100 mL flask containing (4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(2,6-dimethylpyridin-3-yl)methanol (1.51 g, 3.1 mmol, Intermediate 12: step e) was added 1,4-dioxane (50 mL) followed by activated MnO2 (1.3 g, 15 mmol) and the mixture was heated to reflux in an aluminum heating mantle under N2. After 1 hour, TLC (25% acetone:hexane) indicated that the reaction was complete. The contents were filtered while still hot through Celite® and rinsed with THF. The resulting light yellow solution was concentrated and chromatographed by passing through a silica gel column (10% acetone-hexane increasing to 25% acetone) to give the title compound as a light yellowish amorphous solid.

Workup

  1. temperaturethe mixture was heated
  2. filtrationThe contents were filtered while still hot through Celite®
  3. washrinsed with THF
  4. concentrationThe resulting light yellow solution was concentrated
  5. customchromatographed

Sources & evidence

ORD record
ord-de7882d5769245ef8b15890635773a0b
Source dataset
uspto-grants-2016_03
Patent number
US09284308B2

Reaction notes

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