反应详情

温度

45 °C

To a flask containing (4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1,2-dimethyl-1H-imidazol-5-yl)methanol (1.68 g, 3.53. mmol, Intermediate 60: step a) was added 1,4-dioxane (75 mL) and THF (10 mL) which produced a suspension at room temperature. Warming the suspension to 45° C. formed a homogeneous solution. Manganese dioxide (1.5 g, 17.25 mmol) was introduced and the mixture was heated to 80° C. After 60 minutes, the mixture was filtered through a Celite® pad, rinsing with THF. The filtrate was then concentrated to dryness. Tituration with Et2O provided the title compound as a white powder.

1. customproduced a suspension at room temperature
2. customformed a homogeneous solution
3. temperaturethe mixture was heated to 80° C
4. filtrationthe mixture was filtered through a Celite® pad
5. washrinsing with THF
6. concentrationThe filtrate was then concentrated to dryness