反应详情

To a flask containing (4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(3,5-dimethylisoxazol-4-yl)methanol (1.4 g, 2.94 mmol, Intermediate 63: step a) was added THF (75 mL) followed by manganese dioxide (1.1 g, 12.6 mmol). The reaction mixture was heated to reflux for 2 hours, and then the contents were filtered through Celite® and rinsed with additional THF. The effluent was concentrated to provide the title compound as a white amorphous solid which was used without further purification.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 2 hours
3. filtrationthe contents were filtered through Celite®
4. washrinsed with additional THF
5. concentrationThe effluent was concentrated