Dichloromethane → Trifluoroacetic acid

HRID 92666Notes

Reaction equation

HRID 92666 reaction equation
[CH3:1][O:2][C:3]([CH:4]([CH2:5][NH:6][C:7]([O:8][C:9]([CH3:10])([CH3:11])[CH3:12])=[O:13])[NH:14][C:15](=[O:16])[c:17]1[s:18][c:19]([C:24]([NH:25][CH2:26][c:27]2[cH:28][c:29]([OH:33])[cH:30][cH:31][cH:32]2)=[O:34])[cH:20][c:21]1[CH2:22][CH3:23])=[O:35].[Cl:43][CH2:44][Cl:45].[F:36][C:37]([C:38](=[O:39])[OH:40])([F:41])[F:42]>>[CH3:1][O:2][C:3]([CH:4]([CH2:5][NH2:6])[NH:14][C:15](=[O:16])[c:17]1[s:18][c:19]([C:24]([NH:25][CH2:26][c:27]2[cH:28][c:29]([OH:33])[cH:30][cH:31][cH:32]2)=[O:34])[cH:20][c:21]1[CH2:22][CH3:23])=[O:35].[F:36][C:37]([C:38](=[O:39])[OH:40])([F:41])[F:42]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 68226641Methyl 2-[[3-ethyl-5-[(3-hydroxyphenyl)methylcarbamoyl]thiophene-2-carbonyl]amino]-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate

Product 2

HCID 6422Trifluoroacetic acidHCID 77430718Methyl 3-amino-2-[[3-ethyl-5-[(3-hydroxyphenyl)methylcarbamoyl]thiophene-2-carbonyl]amino]propanoate

Sources & evidence

ORD record
ord-f769e6b30ef04c0e8ef1e0fb8f031c5a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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