Hydrochloric Acid → HCID 11845779, compound

HRID 926701Notes

Reaction equation

HRID 926701 reaction equation
[N:1]1[C:2]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:3][N:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=12.[ClH:15]>CCO.[Pd]>[ClH:15].[N:1]1[C:2]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:3][N:4]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=12

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11845418ethyl imidazo[1,2-a]pyrazine-2-carboxylate

Product 1

HCID 11845779HCID 11845779, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10% Pd/C (40 mg) was added to a solution of ethyl imidazo[1,2-a]pyrazine-2-carboxylate (410 mg, 2.15 mmol) and conc.HCl (0.5 mL) in EtOH (9.5 mL) and stirring was continued under a hydrogen atmosphere for 16 h. The reaction mixture was filtered over a celite bed and the filtrate was concentrated under reduced pressure to afford the crude product, which was purified by washing with diethyl ether and dried to afford 400 mg of the title compound as a yellow hygroscopic solid.

Workup

  1. filtrationThe reaction mixture was filtered over a celite bed
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customto afford the crude product, which
  4. customwas purified
  5. washby washing with diethyl ether
  6. customdried

Sources & evidence

ORD record
ord-21f1917f333e42f7b353f31fa3bf9c6e
Source dataset
uspto-grants-2016_03
Patent number
US09289419B2

Reaction notes

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