Hydrochloric Acid → HCID 11845779, compound

HRID 926709Notes

Reaction equation

HRID 926709 reaction equation
[N:1]1[C:2]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:3][N:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=12.[ClH:15]>CCO.[Pd]>[ClH:15].[N:1]1[C:2]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:3][N:4]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=12

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11845418ethyl imidazo[1,2-a]pyrazine-2-carboxylate

Product 1

HCID 11845779HCID 11845779, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10% Pd/C (40 mg) was added to a stirred solution of Ethyl imidazo[1,2-a]pyrazine-2-carboxylate (410 mg, 2.15 mmol) and conc.HCl (0.5 mL) in EtOH (9.5 mL) under inert atmosphere. The reaction mixture was stirred continuously under hydrogen atmosphere for 16 h. The reaction mixture was filtered over a celite bed- and the filtrate was concentrated under reduced pressure to afford a solid product, which was washed with diethyl ether and dried to afford 400 mg of the title compound as a yellow solid.

Workup

  1. filtrationThe reaction mixture was filtered over a celite bed-
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customto afford a solid product, which
  4. washwas washed with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-cc5c8eafdbb44f18b894602d5f694d53
Source dataset
uspto-grants-2016_03
Patent number
US09289419B2

Reaction notes

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