反应详情

Conc. HCl (1 mL) was added to a solution of 3-aminocyclohexanecarboxylic acid (500 mg, 3.49 mmol) in EtOH (20 mL) and stirring was continued at reflux temperature for 3 h. The reaction mixture was concentrated under reduced pressure to afford the crude, which was washed with 10% aqueous NaHCO3 solution, extracted with DCM, dried over anhydrous sodium sulphate to afford 300 mg of the title compound.

1. temperatureat reflux temperature for 3 h
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customto afford the crude, which
4. washwas washed with 10% aqueous NaHCO3 solution
5. extractionextracted with DCM
6. dry with materialdried over anhydrous sodium sulphate