反应详情

温度

27.5 °C

LAH (107 mg, 2.8 mmol) was added portionwise to a solution of ethyl 3-aminocyclohexanecarboxylate (320 mg, 1.87 mmol) in THF (5 mL) at 0° C. and continued stirring at 25-30° C. for 15 h. The reaction mixture was quenched with aqueous saturated sodium sulphate solution, filtered the solid precipitate, washed the solid with THF; the filtrate collected was concentrated under reduced pressure to afford 200 mg of the title compound.

1. customThe reaction mixture was quenched with aqueous saturated sodium sulphate solution
2. filtrationfiltered the solid precipitate
3. washwashed the solid with THF
4. customthe filtrate collected
5. concentrationwas concentrated under reduced pressure