Sulfamide → HCID 89618812, compound

HRID 926725Notes

Reaction equation

HRID 926725 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[C:14]1[CH:19]=[CH:18][N:17]2[N:20]=[CH:21][C:22]([C:23]([NH:25][C@H:26]3[CH2:30][CH2:29][NH:28][CH2:27]3)=[O:24])=[C:16]2[CH:15]=1.[S:31](N)([NH2:34])(=[O:33])=[O:32]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C@H:9]1[CH2:13][CH2:12][CH2:11][N:10]1[C:14]1[CH:19]=[CH:18][N:17]2[N:20]=[CH:21][C:22]([C:23]([NH:25][C@H:26]3[CH2:30][CH2:29][N:28]([S:31](=[O:33])(=[O:32])[NH2:34])[CH2:27]3)=[O:24])=[C:16]2[CH:15]=1

Participants

3

Reactant 2

HCID 82267SulfamideHCID 89618823HCID 89618823, compound

Product 1

HCID 89618812HCID 89618812, compound

Procedure

The title compound was prepared by the method substantially similar to that mentioned in Example-98, using 5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((S)-pyrrolidin-3-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Example-82) and Sulfamide to afford the crude, which was purified by Preparative HPLC [Column: 21.2×250×7 um, Zorbax, XDB,C-18(#22), Mobile phase-A: 10 mmol.NH4OAc in water, B: ACN, Gradient (Time/% B): 0/30, 2/30, 8/90 and Flow rate: 20 mL/min] to afford 26 mg of the title compound.

Workup

  1. customThe title compound was prepared by the method substantially similar to
  2. customto afford the crude, which
  3. customwas purified by Preparative HPLC [Column: 21.2×250×7 um, Zorbax, XDB,C-18(#22), Mobile phase-A: 10 mmol.NH4OAc in water, B: ACN, Gradient (Time/% B): 0/30, 2/30, 8/90 and Flow rate: 20 mL/min]

Sources & evidence

ORD record
ord-f773d24c15e8400bbff1c8b98ed80d8e
Source dataset
uspto-grants-2016_03
Patent number
US09289419B2

Reaction notes

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