Hydrochloric Acid → HCID 89618536, compound

HRID 926728Notes

Reaction equation

HRID 926728 reaction equation
[OH:1][C@H:2]1[CH2:6][CH2:5][N:4]([CH:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)[CH2:3]1.[ClH:20]>O1CCOCC1>[ClH:20].[NH:10]1[CH2:11][CH2:12][CH:7]([N:4]2[CH2:5][CH2:6][C@H:2]([OH:1])[CH2:3]2)[CH2:8][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89618667HCID 89618667, compound

Product 1

HCID 89618536HCID 89618536, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(S)-tert-butyl 4-(3-hydroxypyrrolidin-1-yl)piperidine-1-carboxylate (200 mg, 0.73 mmol) was added to a solution of 4M HCl in Dioxane (4 mL) at 0-5° C. and stirring was continued at 20-35° C. for 3 h. The reaction mixture was concentrated under reduced pressure to afford the crude product. The crude product was purified by washing with diethyl ether to afford 80 mg of the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customto afford the crude product
  3. customThe crude product was purified
  4. washby washing with diethyl ether

Sources & evidence

ORD record
ord-62bb5eec8c5a48c782367c4e8b77b8e8
Source dataset
uspto-grants-2016_03
Patent number
US09289419B2

Reaction notes

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