反应详情

NaN3(1.7 g, 26.14 mmol) and NH4Cl (1.75 g, 32.7 mmol) were added to the solution of benzyl 4-cyanopiperidine-1-carboxylate (1.6 g, 26.14 mmol) in DMF (16 mL) and stirring was continued at 90° C. for 24 h. The reaction mixture was quenched with 10% aqueous citric acid solution, extracted with EtOAc, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 1.45 g of the title compound.

1. customThe reaction mixture was quenched with 10% aqueous citric acid solution
2. extractionextracted with EtOAc
3. dry with materialdried over anhydrous sodium sulphate
4. concentrationconcentrated under reduced pressure