反应详情

N-hydroxysuccinimide (69.8 g, 0.598 mol) was added drop by drop to 1 L of chloroform solution of palmitoyl chloride (165 ml, 0.544 mol) with stirring while cooling with ice, and then triethylamine (83.1 ml, 0.598 mol) was added dropwise over 30 minutes. Then, the whole was stirred while cooled with ice for 30 minutes, allowed to gradually reach room temperature, and stirred for 7 hours. The reaction mixture was washed with water (500 ml×3), then dried over magnesium sulfate, and concentrated under reduced pressure to give 260.3 g (quant) of a colorless solid.

1. temperaturewhile cooling with ice
2. stirringThen, the whole was stirred
3. temperaturewhile cooled with ice for 30 minutes
4. customallowed to gradually reach room temperature
5. stirringstirred for 7 hours
6. washThe reaction mixture was washed with water (500 ml×3)
7. dry with materialdried over magnesium sulfate
8. concentrationconcentrated under reduced pressure
9. customto give 260.3 g (quant) of a colorless solid