HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 926929Generated: November 1, 2026
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 53377717, compound
https://huagongshe.com/reaction/926929
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | N-Hydroxysuccinimide | HCID 80170 | — |
| Reactant | HCID 86675381 | HCID 86675381 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 53377717 | HCID 53377717 | 100% |
Reaction Steps
Compound 9 (66 mg, 93 μmol) was dissolved in acetonitrile (2 mL), N-hydroxysuccinimide (21.5 mg, 187 μmol) and EDCI (36 mg, 187 μmol) were added and the mixture stirred at 20° C. overnight. The solvent was removed under vacuum and the residue was purified over silica gel using dichloromethane/AcOEt (4/1) as eluant to give 45 mg (93 μmol, 60% yield) of a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09290421B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-355123c7f11041df9b486be88fc9c178 |
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| Source note | uspto-grants-2016_03 |
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