1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 2,5-Dioxopyrrolidin-1-yl 4-((3-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy) propan-2-yl)-4-(tributylstannyl)benzyl)(methyl)amino)-4-oxobutanoate

Participants

Reaction Conditions

Reaction Steps

Compound 15 (170 mg, 236 mmol) was dissolved in acetonitrile (5 mL), N-hydroxysuccinimide (54 mg, 472 mmol) and EDCI (90 mg, 472 μmol) were added and the mixture stirred 6 h at 20° C. The solvent was removed under vacuum and the residue was purified over silica gel using dichloromethane/acetone (1/1) as eluant to give 155 mg (190 μmol, 80% yield) of a colorless oil.

Provenance & Evidence