Hydrochloric Acid → HCID 76071674, compound

Participants

Reaction Steps

(3-{4-[2-(4-Methanesulfonyl-phenyl)-ethyl]-phenyl}-isoxazol-4-yl)-carbamic acid tert-butyl ester (88 mg, 0.2 mmol) was dissolved in dioxane (2 mL) and 4N HCl in dioxane (4 mL) was added dropwise. The reaction mixture was stirred at rt for 24.5 h and 3-{4-[2-(4-methanesulfonyl-phenyl)-ethyl]-phenyl}-isoxazol-4-ylamine hydrochloride (53 mg, 71%) was collected by filtration as a white solid. HRMS: 343.111 (M+1)

Provenance & Evidence