Hydrochloric Acid → HCID 76071674, compound

HRID 927041Notes

Reaction equation

HRID 927041 reaction equation
C(OC(=O)[NH:7][C:8]1[C:9]([C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][C:21]3[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][CH:22]=3)=[CH:15][CH:14]=2)=[N:10][O:11][CH:12]=1)(C)(C)C.Cl>O1CCOCC1>[CH3:30][S:27]([C:24]1[CH:23]=[CH:22][C:21]([CH2:20][CH2:19][C:16]2[CH:17]=[CH:18][C:13]([C:9]3[C:8]([NH2:7])=[CH:12][O:11][N:10]=3)=[CH:14][CH:15]=2)=[CH:26][CH:25]=1)(=[O:28])=[O:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90203830HCID 90203830, compound

Product 1

HCID 76071674HCID 76071674, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

(3-{4-[2-(4-Methanesulfonyl-phenyl)-ethyl]-phenyl}-isoxazol-4-yl)-carbamic acid tert-butyl ester (88 mg, 0.2 mmol) was dissolved in dioxane (2 mL) and 4N HCl in dioxane (4 mL) was added dropwise. The reaction mixture was stirred at rt for 24.5 h and 3-{4-[2-(4-methanesulfonyl-phenyl)-ethyl]-phenyl}-isoxazol-4-ylamine hydrochloride (53 mg, 71%) was collected by filtration as a white solid. HRMS: 343.111 (M+1)

Workup

  1. filtration3-{4-[2-(4-methanesulfonyl-phenyl)-ethyl]-phenyl}-isoxazol-4-ylamine hydrochloride (53 mg, 71%) was collected by filtration as a white solid

Sources & evidence

ORD record
ord-238716cc6c0b45c99c0f5ce3c3e918c6
Source dataset
uspto-grants-2016_03
Patent number
US09290465B2

Reaction notes

Loading…