Hydrochloric Acid → HCID 118484003, compound

Participants

Reaction Steps

{3-[5-(4-methanesulfonyl-benzyloxy)-pyridin-2-yl]-isoxazol-4-yl}-carbamic acid tert-butyl ester (70 mg, 0.16 mmol) was dissolved in dioxane (1.5 mL) and treated with 4N HCl in dioxane (1.5 mL, 1.5 mmol). After stirring for 1.5 h, the product 3-[5-(4-methanesulfonyl-benzyloxy)-pyridin-2-yl]-isoxazol-4-ylamine hydrochloride (43 mg, 78%) was isolated as a white solid by filtration. M+1=346.0

Provenance & Evidence