Hydrochloric Acid → HCID 118484003, compound

HRID 927049Notes

Reaction equation

HRID 927049 reaction equation
C(OC(=O)[NH:7][C:8]1[C:9]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]3[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][CH:22]=3)=[CH:15][N:14]=2)=[N:10][O:11][CH:12]=1)(C)(C)C.[ClH:32]>O1CCOCC1>[ClH:32].[CH3:30][S:27]([C:24]1[CH:23]=[CH:22][C:21]([CH2:20][O:19][C:16]2[CH:17]=[CH:18][C:13]([C:9]3[C:8]([NH2:7])=[CH:12][O:11][N:10]=3)=[N:14][CH:15]=2)=[CH:26][CH:25]=1)(=[O:28])=[O:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90203454HCID 90203454, compound

Product 1

HCID 118484003HCID 118484003, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

{3-[5-(4-methanesulfonyl-benzyloxy)-pyridin-2-yl]-isoxazol-4-yl}-carbamic acid tert-butyl ester (70 mg, 0.16 mmol) was dissolved in dioxane (1.5 mL) and treated with 4N HCl in dioxane (1.5 mL, 1.5 mmol). After stirring for 1.5 h, the product 3-[5-(4-methanesulfonyl-benzyloxy)-pyridin-2-yl]-isoxazol-4-ylamine hydrochloride (43 mg, 78%) was isolated as a white solid by filtration. M+1=346.0

Sources & evidence

ORD record
ord-8d8aaa7ef84b495ab356608b67bfc2e4
Source dataset
uspto-grants-2016_03
Patent number
US09290465B2

Reaction notes

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