1-Ethynyl-3,5-difluorobenzene → 3,4-bis(Benzyloxy)-6-[(3,5-difluorophenyl)ethynyl]pyridazine

HRID 927067Notes

Reaction equation

HRID 927067 reaction equation
C(OC1N=NC(C#CC2C=CC=CC=2)=CC=1OCC1C=CC=CC=1)C1C=CC=CC=1.[CH2:31]([O:38][C:39]1[N:40]=[N:41][C:42](Cl)=[CH:43][C:44]=1[O:45][CH2:46][C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.[C:54]([C:56]1[CH:61]=[C:60]([F:62])[CH:59]=[C:58]([F:63])[CH:57]=1)#[CH:55]>>[CH2:31]([O:38][C:39]1[N:40]=[N:41][C:42]([C:55]#[C:54][C:56]2[CH:61]=[C:60]([F:62])[CH:59]=[C:58]([F:63])[CH:57]=2)=[CH:43][C:44]=1[O:45][CH2:46][C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

4

Reactant 3

HCID 42068061-Ethynyl-3,5-difluorobenzeneHCID 122134743,4-Bis(benzyloxy)-6-chloropyridazine2×HCID 712704193,4-Bis(benzyloxy)-6-(phenylethynyl)pyridazine2×

Product 1

HCID 712700173,4-bis(Benzyloxy)-6-[(3,5-difluorophenyl)ethynyl]pyridazine

Procedure

Prepared as described for 3,4-bis(benzyloxy)-6-(phenylethynyl)pyridazine (Intermediate 2) from 3,4-bis(benzyloxy)-6-chloropyridazine (Intermediate 1) and 1-ethynyl-3,5-difluorobenzene.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a1e1bd7ce6aa4222bbcc1905fa25e1d5
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

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