3,4-Bis(benzyloxy)-6-chloropyridazine → 3,4-bis(Benzyloxy)-6-[(3-fluorophenyl)methyl]pyridazine

HRID 927105노트

반응식

HRID 927105 반응식
[CH2:1]([O:8][C:9]1[N:10]=[N:11][C:12]([CH2:23][C:24]2[CH:29]=[CH:28][C:27](F)=[CH:26][CH:25]=2)=[CH:13][C:14]=1[O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC1N=NC(Cl)=CC=1OCC1C=CC=CC=1)C1C=CC=CC=1.[Cl-].[F:55]C1C=C(C=CC=1)C[Zn+]>>[CH2:1]([O:8][C:9]1[N:10]=[N:11][C:12]([CH2:23][C:24]2[CH:25]=[CH:26][CH:27]=[C:28]([F:55])[CH:29]=2)=[CH:13][C:14]=1[O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 122134743,4-Bis(benzyloxy)-6-chloropyridazine2회HCID 712704273,4-bis(Benzyloxy)-6-[(4-fluorophenyl)methyl]pyridazine2회HCID 178505699HCID 178505699, 화합물

생성물 1

HCID 712704603,4-bis(Benzyloxy)-6-[(3-fluorophenyl)methyl]pyridazine수율 32%

실험 절차

Prepared as described for 3,4-bis(benzyloxy)-6-[(4-fluorophenyl)methyl]pyridazine (Intermediate 51) from 3,4-bis(benzyloxy)-6-chloropyridazine (Intermediate 1) and (3-fluorobenzyl)zinc(II) chloride in 32% yield.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-44572d934ce84625b01fcebd044a1bba
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290456B2

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