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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927105Generated: October 26, 2026

3,4-Bis(benzyloxy)-6-chloropyridazine → 3,4-bis(Benzyloxy)-6-[(3-fluorophenyl)methyl]pyridazine

https://huagongshe.com/reaction/927105

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-Bis(benzyloxy)-6-chloropyridazineHCID 12213474—
Reactant3,4-bis(Benzyloxy)-6-[(4-fluorophenyl)methyl]pyridazineHCID 71270427—
ReactantHCID 178505699HCID 178505699—
Product3,4-bis(Benzyloxy)-6-[(3-fluorophenyl)methyl]pyridazineHCID 7127046032%

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-[(4-fluorophenyl)methyl]pyridazine (Intermediate 51) from 3,4-bis(benzyloxy)-6-chloropyridazine (Intermediate 1) and (3-fluorobenzyl)zinc(II) chloride in 32% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-44572d934ce84625b01fcebd044a1bba
Source noteuspto-grants-2016_03