反应详情

Prepared as described for 4-hydroxy-6-(2-phenethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-[(2,4-difluorophenyl)ethynyl]pyridazine (Intermediate 21) except that the reaction was carried out in a mixture of ethanol and tetrahydrofuran (1:1). The crude material was purified by reverse phase chromatography (25 g C18) cartridge eluting with 5-100% acetonitrile/water with acidic modifier and the appropriate fractions combined to give a yellow solid. This was recrystallised from ethanol to give a white solid (yield=26%).

1. customPrepared
2. customThe crude material was purified by reverse phase chromatography (25 g C18) cartridge
3. washeluting with 5-100% acetonitrile/water with acidic modifier
4. customto give a yellow solid
5. customThis was recrystallised from ethanol