反应详情

Prepared as described for 4-hydroxy-6-(2-phenethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-[(3-chloromethyl)phenyl)ethynyl]pyridazine (Intermediate 24) except that the reaction was carried out in ethyl acetate. The crude material was purified by reverse phase chromatography (50 g C18) cartridge eluting with 5-100% acetonitrile/water with acidic modifier and the appropriate fractions combined to give an orange solid. This was recrystallised from ethyl acetate to give a white solid (yield=32%).

1. customPrepared
2. customThe crude material was purified by reverse phase chromatography (50 g C18) cartridge
3. washeluting with 5-100% acetonitrile/water with acidic modifier
4. customto give an orange solid
5. customThis was recrystallised from ethyl acetate