HCID 71270138, compound → HCID 178518783, compound

HRID 927141Notes

Reaction equation

HRID 927141 reaction equation
C([O:8][C:9]1[N:10]=[N:11][C:12]([C:23]2([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:25][CH2:24]2)=[CH:13][C:14]=1[O:15]CC1C=CC=CC=1)C1C=CC=CC=1>C(OCC)(=O)C>[OH:15][C:14]1[C:9](=[O:8])[NH:10][N:11]=[C:12]([C:23]2([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH2:25][CH2:24]2)[CH:13]=1

Participants

3

Reactant 1

HCID 71270138HCID 71270138, compound2×

Product 1

HCID 178518783HCID 178518783, compoundYield 27%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Prepared as described for 4-hydroxy-6-(2-phenethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-(1-phenylcyclopropyl)pyridazine (Intermediate 26) except that the reaction was carried out in ethyl acetate. The crude material was recrystallised from ethyl acetate to give a pink solid (yield=27%).

Workup

  1. customPrepared
  2. customThe crude material was recrystallised from ethyl acetate

Sources & evidence

ORD record
ord-d99c6ccbbc07499bb6298160ae5767bb
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

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