3,4-Bis(benzyloxy)-6-((4-chlorophenyl)ethynyl)pyridazine → HCID 178518825, compound

HRID 927146Notes

Reaction equation

HRID 927146 reaction equation
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28]([C:39]#[C:40][C:41]2[CH:46]=[CH:45][C:44]([Cl:47])=[CH:43][CH:42]=2)=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1>O1CCCC1>[Cl:47][C:44]1[CH:45]=[CH:46][C:41]([CH2:40][CH2:39][C:28]2[CH:29]=[C:30]([OH:31])[C:25](=[O:24])[NH:26][N:27]=2)=[CH:42][CH:43]=1

Participants

4

Reactant 2

HCID 712697953,4-Bis(benzyloxy)-6-((4-chlorophenyl)ethynyl)pyridazine2×HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

Product 1

HCID 178518825HCID 178518825, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared by the same method as for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-((4-chlorophenyl)ethynyl)pyridazine (Intermediate 34) except that the solvent used for the hydrogenation was tetrahydrofuran and the final compound was recrystallised from a mixture of ethyl acetate and heptane.

Workup

  1. customthe final compound was recrystallised from a mixture of ethyl acetate and heptane

Sources & evidence

ORD record
ord-13a7b9e78ddc43eb8be9744829a94de2
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

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