HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 178518831, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 3,4-Bis(benzyloxy)-6-((4-(difluoromethoxy)phenyl)ethynyl)pyridazine | HCID 71270248 | — |
| Reactant | 3-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One | HCID 178518808 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178518831 | HCID 178518831 | — |
Reaction Steps
Prepared by the same method as for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-((4-(difluoromethoxy)phenyl)ethynyl)pyridazine (Intermediate 36) except that the solvent mixture used for the hydrogenation was made up of tetrahydrofuran and methanol and the final material was recrystallised from 2-propanol and heptanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290456B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-fe04ebdaa2f74c3d8e18a76cac28f79a |
| Source note | uspto-grants-2016_03 |