Tetrahydrofuran → HCID 178518831, compound

HRID 927149Notes

Reaction equation

HRID 927149 reaction equation
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28]([C:39]#[C:40][C:41]2[CH:46]=[CH:45][C:44]([O:47][CH:48]([F:50])[F:49])=[CH:43][CH:42]=2)=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1.O1CCCC1>CO>[F:50][CH:48]([F:49])[O:47][C:44]1[CH:43]=[CH:42][C:41]([CH2:40][CH2:39][C:28]2[CH:29]=[C:30]([OH:31])[C:25](=[O:24])[NH:26][N:27]=2)=[CH:46][CH:45]=1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 71270248HCID 71270248, compound2×HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

Product 1

HCID 178518831HCID 178518831, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared by the same method as for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-((4-(difluoromethoxy)phenyl)ethynyl)pyridazine (Intermediate 36) except that the solvent mixture used for the hydrogenation was made up of tetrahydrofuran and methanol and the final material was recrystallised from 2-propanol and heptanes.

Workup

  1. customthe final material was recrystallised from 2-propanol and heptanes

Sources & evidence

ORD record
ord-fe04ebdaa2f74c3d8e18a76cac28f79a
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

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