Tetrahydrofuran → HCID 178518832, compound

HRID 927150Notes

Reaction equation

HRID 927150 reaction equation
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28]([C:39]#[C:40][C:41]2[CH:46]=[CH:45][C:44]([O:47][C:48]([F:51])([F:50])[F:49])=[CH:43][CH:42]=2)=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1.O1CCCC1>CO>[F:51][C:48]([F:49])([F:50])[O:47][C:44]1[CH:45]=[CH:46][C:41]([CH2:40][CH2:39][C:28]2[CH:29]=[C:30]([OH:31])[C:25](=[O:24])[NH:26][N:27]=2)=[CH:42][CH:43]=1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 71270488HCID 71270488, compound2×HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

Product 1

HCID 178518832HCID 178518832, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared by the same method as for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-((4-(trifluoromethoxy)phenyl)ethynyl)pyridazine (Intermediate 37) except that the solvent mixture used for the hydrogenation was made up of tetrahydrofuran and methanol and the final compound was recrystallised from MTBE and heptane.

Workup

  1. customthe final compound was recrystallised from MTBE and heptane

Sources & evidence

ORD record
ord-018a0f4c08ae47fc9ec3b12523c354a4
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

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