HCID 71269819, compound → HCID 178518785, compound

HRID 927152Notes

Reaction equation

HRID 927152 reaction equation
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28]([C:39]2([C:42]3[CH:47]=[CH:46][C:45]([F:48])=[CH:44][CH:43]=3)[CH2:41][CH2:40]2)=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1>C(OCC)(=O)C>[F:48][C:45]1[CH:44]=[CH:43][C:42]([C:39]2([C:28]3[CH:29]=[C:30]([OH:31])[C:25](=[O:24])[NH:26][N:27]=3)[CH2:41][CH2:40]2)=[CH:47][CH:46]=1

Participants

4

Reactant 2

HCID 71269819HCID 71269819, compound2×HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

Product 1

HCID 178518785HCID 178518785, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Prepared by the same method as for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-[1-(4-fluorophenyl)cyclopropyl]pyridazine (Intermediate 42) except that the solvent used for the hydrogenation was ethyl acetate and the product was recrystallised from a mixture of ethyl acetate and MTBE.

Workup

  1. customthe product was recrystallised from a mixture of ethyl acetate and MTBE

Sources & evidence

ORD record
ord-0c1f4adf06874259be82761078af931c
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

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