3,4-bis(Benzyloxy)-6-[(3-chlorophenyl)methyl]pyridazine → HCID 178518797, compound

HRID 927158Notes

Reaction equation

HRID 927158 reaction equation
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28]([CH2:39][C:40]2[CH:45]=[CH:44][CH:43]=[C:42]([Cl:46])[CH:41]=2)=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1>C(OCC)(=O)C>[Cl:46][C:42]1[CH:41]=[C:40]([CH:45]=[CH:44][CH:43]=1)[CH2:39][C:28]1[CH:29]=[C:30]([OH:31])[C:25](=[O:24])[NH:26][N:27]=1

Participants

4

Reactant 2

HCID 712702713,4-bis(Benzyloxy)-6-[(3-chlorophenyl)methyl]pyridazine2×HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

Product 1

HCID 178518797HCID 178518797, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Prepared in the same way as 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-[(3-chlorophenyl)methyl]pyridazine (Intermediate 48) except that the solvent used for the hydrogenation was ethyl acetate and the product was recrystallised from ethyl acetate.

Workup

  1. customthe product was recrystallised from ethyl acetate

Sources & evidence

ORD record
ord-97df71cb84684cac8e56d395fa4f8fe7
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

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