HCID 71270105, compound → HCID 178518793, compound

HRID 927160Notes

Reaction equation

HRID 927160 reaction equation
[OH:1][C:2]1[C:3](=[O:16])[NH:4][N:5]=[C:6]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12]C=2)[CH:7]=1.C(OC1N=NC(CC2CCCCC2)=CC=1OCC1C=CC=CC=1)C1C=CC=CC=1>C(OCC)(=O)C>[CH:9]1([CH2:8][C:6]2[CH:7]=[C:2]([OH:1])[C:3](=[O:16])[NH:4][N:5]=2)[CH2:10][CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 71270105HCID 71270105, compound2×HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

Product 1

HCID 178518793HCID 178518793, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Prepared in the same way as 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-(cyclohexylmethyl)pyridazine (Intermediate 50) except that the solvent used for the hydrogenation was ethyl acetate and the product was recrystallised from a mixture of MTBE and heptanes.

Workup

  1. customthe product was recrystallised from a mixture of MTBE and heptanes

Sources & evidence

ORD record
ord-671909a70f764a5eb005db0814eba5a0
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

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