HCID 71270194, compound → HCID 178518791, compound

HRID 927175Notes

Reaction equation

HRID 927175 reaction equation
[OH:1][C:2]1[C:3](=[O:16])[NH:4][N:5]=[C:6]([CH2:8][CH2:9][C:10]2[CH:15]=CC=CC=2)[CH:7]=1.C(OC1N=NC(C=C2CC2)=CC=1OCC1C=CC=CC=1)C1C=CC=CC=1>CO>[CH:9]1([CH2:8][C:6]2[CH:7]=[C:2]([OH:1])[C:3](=[O:16])[NH:4][N:5]=2)[CH2:10][CH2:15]1

Participants

4

Reactant 2

HCID 71270194HCID 71270194, compound2×HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

Product 1

HCID 178518791HCID 178518791, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared in the same manner as 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-(cyclopropylidenemethyl)pyridazine (Intermediate 65) except that methanol was used as the reaction solvent. The crude compound was purified by preparative HPLC to yield 6-(cyclopropylmethyl)-4-hydroxypyridazin-3(2H)-one (46% yield)

Workup

  1. customThe crude compound was purified by preparative HPLC

Sources & evidence

ORD record
ord-0ad93e610cd94918ac5419ff61c8dccb
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

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