HCID 90310891, compound → HCID 90311549, compound

HRID 927260Notes

Reaction equation

HRID 927260 reaction equation
CS([C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][C:12]=1[CH:13]1[N:18]([S:19]([CH3:22])(=[O:21])=[O:20])[C:17](=[O:23])[N:16]([C:24]2[CH:29]=[CH:28][N:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[CH:25]=2)[C:15]2[CH2:34][CH2:35][C:36](=[O:37])[C:14]1=2)[C:8]#[N:9])(=O)=O.O=C1N(C2C=CN=C(C(F)(F)F)C=2)C2CCC(=O)C=2C(C2C=CC(C#N)=CC=2)N1>>[CH3:22][S:19]([N:18]1[CH:13]([C:12]2[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][CH:5]=2)[C:14]2[C:36](=[O:37])[CH2:35][CH2:34][C:15]=2[N:16]([C:24]2[CH:29]=[CH:28][N:27]=[C:26]([C:30]([F:31])([F:32])[F:33])[CH:25]=2)[C:17]1=[O:23])(=[O:21])=[O:20]

Participants

3

Reactant 2

HCID 90310891HCID 90310891, compoundHCID 90310960HCID 90310960, compound

Product 1

HCID 90311549HCID 90311549, compound

Procedure

The title compound is prepared in analogy to 3-(methylsulfonyl)-4-(3-(methylsulfonyl)-2,5-dioxo-1-(2-(trifluoromethyl)pyridin-4-yl)-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]-pyrimidin-4-yl)benzonitrile (example 39), using 4-(2,5-dioxo-1-(2-(trifluoromethyl)pyridin-4-yl)-2,3,4, 5,6,7-hexahydro-1H-cyclopenta[d]pyrimidin-4-yl)benzonitrile (example 15.5, 60 mg, 0.15 mmol) as starting material. Yield: 30 mg; ESI mass spectrum [M+H]+=477; Retention time HPLC: 0.99 min (Z018_S04).

Workup

  1. custom0.99 min (Z018_S04)

Sources & evidence

ORD record
ord-14ea446ed54b4a8cb111a07c8b9f1976
Source dataset
uspto-grants-2016_03
Patent number
US09290459B1

Reaction notes

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