HRID927300

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID517981

Methyl 3-(bromomethyl)benzoate

C9H9BrO2

HCID16658240

6-Fluoroquinazoline-2,4(1H,3H)-dione

C8H5FN2O2

结构：O=C(O)c1cccc(Cn2c(=O)[nH]c(=O)c3cc(F)ccc32)c1

HCID68388768

未命名化合物

结构：COC(=O)c1cccc(Cn2c(=O)[nH]c(=O)c3ccccc32)c1

HCID68388893

未命名化合物

PRODUCTS

生成物

结构：O=C(c1cccc(Cn2c(=O)[nH]c(=O)c3cccc(F)c32)c1)N1CCN(C(=O)C2CCCCC2)CC1

HCID68389053

未命名化合物

PROCEDURE

实验过程

The following compounds were prepared from 6-fluoro-1-(3-carboxybenzyl)quinazoline-2,4(1H,3H)-dione (prepared from 6-fluoroquinazoline-2,4(1H,3H)-dione and methyl 3-(bromomethyl)benzoate using procedures similar to those of compounds of Examples 1 and 2), and the corresponding substituted piperazine using a procedure similar to those described for the synthesis of compound of Example 3.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6cc5547763b24302809037b4e85eca5c
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09290460B2
来源说明: uspto-grants-2016_03

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19](O)=[O:20])[CH:14]=1)[C:7](=[O:22])[NH:6][C:5]2=[O:23].F[C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][CH:34]=1)N[C:30](=O)[NH:29][C:28]2=[O:36].BrCC1C=C(C=CC=1)C(OC)=O.COC(C1C=[C:55](C=CC=1)[CH2:56][N:57]1C2C(=CC=CC=2)C(=O)N[C:58]1=O)=O>>[CH:27]1([C:28]([N:29]2[CH2:55][CH2:56][N:57]([C:19]([C:15]3[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=3)[CH2:12][N:8]3[C:3]4[C:4](=[CH:9][CH:10]=[CH:11][C:2]=4[F:1])[C:5](=[O:23])[NH:6][C:7]3=[O:22])=[O:20])[CH2:58][CH2:30]2)=[O:36])[CH2:32][CH2:33][CH2:34][CH2:25][CH2:26]1