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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927300Generated: November 1, 2026

Methyl 3-(bromomethyl)benzoate → 1-(3-(4-(Cyclohexylcarbonyl)piperazine-1-carbonyl)benzyl)-8-fluoroquinazoline-2,4(1H,3H)-dione

https://huagongshe.com/reaction/927300

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 3-(bromomethyl)benzoateHCID 517981—
Reactant6-Fluoroquinazoline-2,4(1H,3H)-dioneHCID 16658240—
Reactant6-fluoro-1-(3-carboxybenzyl)quinazoline-2,4(1H,3H)-dioneHCID 68388768—
ReactantHCID 68388893HCID 68388893—
Product1-(3-(4-(Cyclohexylcarbonyl)piperazine-1-carbonyl)benzyl)-8-fluoroquinazoline-2,4(1H,3H)-dioneHCID 68389053—

Reaction Steps

The following compounds were prepared from 6-fluoro-1-(3-carboxybenzyl)quinazoline-2,4(1H,3H)-dione (prepared from 6-fluoroquinazoline-2,4(1H,3H)-dione and methyl 3-(bromomethyl)benzoate using procedures similar to those of compounds of Examples 1 and 2), and the corresponding substituted piperazine using a procedure similar to those described for the synthesis of compound of Example 3.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290460B2
Source datasetuspto-grants-2016_03
ORD IDord-6cc5547763b24302809037b4e85eca5c
Source noteuspto-grants-2016_03