HRID927301

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16658240

6-Fluoroquinazoline-2,4(1H,3H)-dione

C8H5FN2O2

HCID22645461

Methyl 5-(bromomethyl)-2-fluorobenzoate

C9H8BrFO2

结构：COC(=O)c1cccc(Cn2c(=O)[nH]c(=O)c3ccccc32)c1

HCID68388893

未命名化合物

结构：O=C(O)c1cc(Cn2c(=O)[nH]c(=O)c3cc(F)ccc32)ccc1F

HCID68388908

未命名化合物

PRODUCTS

生成物

结构：O=C(c1cccc(Cn2c(=O)[nH]c(=O)c3cc(F)ccc32)c1)N1CCN(C(=O)C2CCCC2)CC1

HCID68389141

未命名化合物

PROCEDURE

实验过程

The following compounds were prepared from 6-fluoro-1-(3-carboxy-4-fluorobenzyl)quinazoline-2,4(1H,3H)-dione (prepared from 6-fluoroquinazoline-2,4(1H,3H)-dione and methyl 5-(bromomethyl)-2-fluorobenzoate using procedures similar to those of compounds of Examples 1 and 2), and the corresponding substituted piperazine using a procedure similar to those described for the synthesis of compound of Example 3.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1cfb8a532742415cb5d52531db9d08a9
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09290460B2
来源说明: uspto-grants-2016_03

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13]1[CH:18]=[CH:17][C:16](F)=[C:15]([C:20](O)=[O:21])[CH:14]=1)[C:7](=[O:23])[NH:6][C:5]2=[O:24].FC1[CH:27]=[C:28]2[C:33](=[CH:34][CH:35]=1)N[C:31](=O)[NH:30][C:29]2=[O:37].BrCC1C=CC(F)=C(C=1)C(OC)=O.COC(C1C=[C:57](C=CC=1)[CH2:58][N:59]1C2C(=CC=CC=2)C(=O)N[C:60]1=O)=O>>[CH:28]1([C:29]([N:30]2[CH2:31][CH2:60][N:59]([C:20]([C:15]3[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=3)[CH2:12][N:8]3[C:9]4[C:4](=[CH:3][C:2]([F:1])=[CH:11][CH:10]=4)[C:5](=[O:24])[NH:6][C:7]3=[O:23])=[O:21])[CH2:58][CH2:57]2)=[O:37])[CH2:27][CH2:35][CH2:34][CH2:33]1