Triphenylphosphine → HCID 84647948, compound

HRID 927368Notes

Reaction equation

HRID 927368 reaction equation
[O:1]1[CH:5]=[N:4][N:3]=[C:2]1[C:6]([NH:9]C(=O)OCC1C=CC=CC=1)([CH3:8])[CH3:7].[H][H].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>C(O)C.[Pd]>[CH3:7][C:6]([NH2:9])([C:2]1[O:1][CH:5]=[N:4][N:3]=1)[CH3:8]

Participants

6

Reactant 3

HCID 11776TriphenylphosphineHCID 71087339HCID 71087339, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 84647948HCID 84647948, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of benzyl 2-(1,3,4-oxadiazol-2-yl)propan-2-ylcarbamate (1 g, 30% purity) and 10% Pd/C (0.06 g) in ethanol (30 mL) was charged with hydrogen balloon and stirred at room temperature overnight. After filtration, it was concentrated to give crude product which was directly used in the next reaction step without further purification but still contained OPPh3 and PPh3; MS: m/e 128.1 [M+H]+.

Workup

  1. filtrationAfter filtration, it
  2. concentrationwas concentrated
  3. customto give crude product which

Sources & evidence

ORD record
ord-f4a9bec7218d42578bcbb57d1ced5778
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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