6-(3-Chlorophenyl)picolinic acid → 6-(3-Chloro-phenyl)-pyridine-2-carboxylic acid ((S)-3-methyl-1-thiazol-2-yl-butyl)-amide

HRID 927444Notes

Reaction equation

HRID 927444 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:17][CH:18]([CH3:27])[CH2:19][C@@H:20]([C:22]1[S:23][CH:24]=[CH:25][N:26]=1)[NH2:21]>>[CH3:17][CH:18]([CH3:27])[CH2:19][C@H:20]([NH:21][C:14]([C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:16])[C:22]1[S:23][CH:24]=[CH:25][N:26]=1

Participants

3

Reactant 2

HCID 247301356-(3-Chlorophenyl)picolinic acidHCID 42078239(S)-alpha-(2-methylpropyl)-2-thiazolemethanamine

Product 1

HCID 711055676-(3-Chloro-phenyl)-pyridine-2-carboxylic acid ((S)-3-methyl-1-thiazol-2-yl-butyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(3-chlorophenyl)-2-pyridinecarboxylic acid (CAN 863704-38-5) and (S)-α-(2-methylpropyl)-2-thiazolemethanamine as starting materials, MS (LC/MS): 386.1 [M+H]+.

Sources & evidence

ORD record
ord-ce7a4f24569642db9920abcfbf0ebe0d
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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