6-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid → 6-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid ((S)-2-cyclopropyl-1-thiazol-2-yl-ethyl)-amide

HRID 927457Notes

Reaction equation

HRID 927457 reaction equation
C1(COC2N=C(C(O)=O)C=CC=2C)CC1.[CH:16]1([CH2:19][C@H:20]([NH:26][C:27]([C:29]2[CH:34]=[CH:33][C:32]([CH:35]3CCOCC3)=[C:31]([O:41][CH2:42][CH:43]3[CH2:45][CH2:44]3)[N:30]=2)=[O:28])[C:21]2[S:22][CH:23]=[CH:24][N:25]=2)[CH2:18][CH2:17]1>>[CH:16]1([CH2:19][C@H:20]([NH:26][C:27]([C:29]2[CH:34]=[CH:33][C:32]([CH3:35])=[C:31]([O:41][CH2:42][CH:43]3[CH2:45][CH2:44]3)[N:30]=2)=[O:28])[C:21]2[S:22][CH:23]=[CH:24][N:25]=2)[CH2:17][CH2:18]1

Participants

3

Reactant 2

HCID 710875996-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acidHCID 711055706-Cyclopropylmethoxy-5-(tetrahydro-pyran-4-yl)-pyridine-2-carboxylic acid ((S)-2-cyclopropyl-1-thiazol-2-yl-ethyl)-amide

Product 1

HCID 711055756-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid ((S)-2-cyclopropyl-1-thiazol-2-yl-ethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid (Example 36 d) and (S)-2-cyclopropyl-1-thiazol-2-yl-ethylamine (Example 59 b) as starting materials, MS (LC/MS): 358.2 [M+H]+.

Sources & evidence

ORD record
ord-049ba77d15744da292ed5e1020a3b358
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

Loading…