2-Amino-N,2-dimethylpropanamide → 6-(3-Chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid (1-methyl-1-methylcarbamoyl-ethyl)-amide

HRID 927459Notes

Reaction equation

HRID 927459 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][C:9]=2[CH:17]2[CH2:19][CH2:18]2)[CH:5]=[CH:6][CH:7]=1.[NH2:20][C:21]([CH3:27])([CH3:26])[C:22]([NH:24][CH3:25])=[O:23]>>[CH3:26][C:21]([NH:20][C:14]([C:12]1[CH:11]=[CH:10][C:9]([CH:17]2[CH2:19][CH2:18]2)=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:16])([C:22](=[O:23])[NH:24][CH3:25])[CH3:27]

Participants

3

Reactant 2

HCID 187922142-Amino-N,2-dimethylpropanamideHCID 710874536-(3-Chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid

Product 1

HCID 711130516-(3-Chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid (1-methyl-1-methylcarbamoyl-ethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(3-chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid (Example 48 e) and 2-amino-N,2-dimethyl-propanamide (CAN 106914-07-2) as starting materials, MS (EI) m/e: 372.1 [M+H]+.

Sources & evidence

ORD record
ord-5c49a3666b97493f905b90dc5268c9a5
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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