2-(5-Methyl-1,2,4-oxadiazol-3-yl)propan-2-amine → 7,7-dimethyl-N-(2-(5-methyl-1,2,4-oxadiazol-3-yl)propan-2-yl)-5,6,7,8-tetrahydroquinoline-2-carboxamide

HRID 927576Notes

Reaction equation

HRID 927576 reaction equation
[CH3:1][C:2]1([CH3:15])[CH2:11][C:10]2[N:9]=[C:8]([C:12]([OH:14])=O)[CH:7]=[CH:6][C:5]=2[CH2:4][CH2:3]1.[CH3:16][C:17]([CH3:25])([C:19]1[N:23]=[C:22]([CH3:24])[O:21][N:20]=1)[NH2:18]>>[CH3:15][C:2]1([CH3:1])[CH2:11][C:10]2[N:9]=[C:8]([C:12]([NH:18][C:17]([C:19]3[N:23]=[C:22]([CH3:24])[O:21][N:20]=3)([CH3:25])[CH3:16])=[O:14])[CH:7]=[CH:6][C:5]=2[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 435592512-(5-Methyl-1,2,4-oxadiazol-3-yl)propan-2-amineHCID 710874727,7-Dimethyl-5,6,7,8-tetrahydro-quinoline-2-carboxylic acid

Product 1

HCID 710876567,7-dimethyl-N-(2-(5-methyl-1,2,4-oxadiazol-3-yl)propan-2-yl)-5,6,7,8-tetrahydroquinoline-2-carboxamide

Procedure

The title compound was synthesized in analogy to Example 1, using 7,7-dimethyl-5,6,7,8-tetrahydro-quinoline-2-carboxylic acid (Example 143 d) and α,α,5-trimethyl-1,2,4-oxadiazole-3-methanamine (CAN 1153831-97-0) as starting materials, LC-MS (UV peak area/EIC) 100%, 329.1977 (M+H)+.

Sources & evidence

ORD record
ord-9482680e6aa0462cb19b2588d082ce94
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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