2-Amino-2-methyl-1-propanol → N-(1-hydroxy-2-methylpropan-2-yl)-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-2-carboxamide

HRID 927577Notes

Reaction equation

HRID 927577 reaction equation
[CH3:1][C:2]1([CH3:15])[CH2:11][C:10]2[N:9]=[C:8]([C:12]([OH:14])=O)[CH:7]=[CH:6][C:5]=2[CH2:4][CH2:3]1.[NH2:16][C:17]([CH3:21])([CH3:20])[CH2:18][OH:19]>>[OH:19][CH2:18][C:17]([NH:16][C:12]([C:8]1[CH:7]=[CH:6][C:5]2[CH2:4][CH2:3][C:2]([CH3:1])([CH3:15])[CH2:11][C:10]=2[N:9]=1)=[O:14])([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 710874727,7-Dimethyl-5,6,7,8-tetrahydro-quinoline-2-carboxylic acid

Product 1

HCID 71087724N-(1-hydroxy-2-methylpropan-2-yl)-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-2-carboxamide

Procedure

The title compound was synthesized in analogy to Example 1, using 7,7-dimethyl-5,6,7,8-tetrahydro-quinoline-2-carboxylic acid (Example 143 d) and 2-amino-2-methyl-1-propanol (CAN 124-68-5) as starting materials, LC-MS (UV peak area/EIC) 99.7%, 277.1910(M+H)+.

Sources & evidence

ORD record
ord-a445833fe24444158b0dd1004ac2ef57
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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