Toluene → 2-((2-Chloropyridin-4-yloxy)methyl)-3,5-difluoropyridine

HRID 92765Notes

Reaction equation

HRID 92765 reaction equation
[C:19](=[O:20])([O-:21])[O-:22].[CH3:39][c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1.[Cl:11][c:12]1[n:13][cH:14][cH:15][c:16]([I:18])[cH:17]1.[Cs+:23].[Cs+:24].[Cu:46][I:47].[F:1][c:2]1[c:3]([CH2:9][OH:10])[n:4][cH:5][c:6]([F:8])[cH:7]1.[cH:25]1[cH:26][c:27]2[cH:28][cH:29][c:30]3[c:31]([c:32]2[n:33][cH:34]1)[n:35][cH:36][cH:37][cH:38]3>>[F:1][c:2]1[c:3]([CH2:9][O:10][c:16]2[cH:15][cH:14][n:13][c:12]([Cl:11])[cH:17]2)[n:4][cH:5][c:6]([F:8])[cH:7]1

Participants

8

Reactant 7

HCID 1140TolueneHCID 13181,10-PhenanthrolineHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 104967Cesium cation2×HCID 15165112-Chloro-4-iodopyridineHCID 53414314(3,5-Difluoropyridin-2-YL)methanol

Product 1

HCID 580922842-((2-Chloropyridin-4-yloxy)methyl)-3,5-difluoropyridine

Sources & evidence

ORD record
ord-8530cec4de114c4eac5ad2105ebbcb13
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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