Hydrochloric Acid → HCID 86674783, compound

HRID 927740Notes

Reaction equation

HRID 927740 reaction equation
C(OC(=O)[NH:7][C:8]([C:11]1[N:15]=[C:14]([NH2:16])[O:13][N:12]=1)([CH3:10])[CH3:9])(C)(C)C.[ClH:18].O1CCOCC1>C(O)C>[ClH:18].[NH2:7][C:8]([C:11]1[N:15]=[C:14]([NH2:16])[O:13][N:12]=1)([CH3:10])[CH3:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 71087515HCID 71087515, compound

Product 1

HCID 86674783HCID 86674783, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of [1-(5-amino-[1,2,4]oxadiazol-3-yl)-1-methyl-ethyl]carbamic acid tert-butyl ester (1.6 g, 6.6 mmol) in ethanol (30 mL) was added HCl in dioxane (4 M, 6.6 ml, 26.4 mmol) and the reaction mixture was stirred 16 hours at room temperature. The reaction mixture was concentrated in vacuo and dried by applying high vacuum at 40° C. for 4 hours to give the title compound as off-white solid (1.2 g, quant.); LC-MS (UV peak area/ESI) 99.9%, 143.0927 (M+H)+.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customdried
  3. customat 40° C.
  4. customfor 4 hours

Sources & evidence

ORD record
ord-499afbb5f024491ea4847465eff61433
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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