Hydrochloric Acid → HCID 86674792, compound

HRID 927757Notes

Reaction equation

HRID 927757 reaction equation
C(OC(=O)[NH:7][C:8]([C:11]1[O:15][N:14]=[C:13]([NH2:16])[N:12]=1)([CH3:10])[CH3:9])(C)(C)C.[ClH:18].O1CCOCC1>C(O)C>[ClH:18].[NH2:7][C:8]([C:11]1[O:15][N:14]=[C:13]([NH2:16])[N:12]=1)([CH3:10])[CH3:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 71087789HCID 71087789, compound

Product 1

HCID 86674792HCID 86674792, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of [1-(3-amino-[1,2,4]oxadiazol-5-yl)-1-methyl-ethyl]carbamic acid tert-butyl ester (100 mg, 0.41 mmol) in ethanol (2 mL) was added HCl in dioxane (4 M, 0.41 ml, 1.65 mmol) and the reaction mixture was stirred 16 hours at room temperature. The reaction mixture was concentrated in vacuo and dried by applying high vacuum at 40° C. for 4 hours to give the title compound as white solid (75 mg, quant.); LC-MS (UV peak area/ESI) nd, 143.0928 (M+H)+.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customdried
  3. customat 40° C.
  4. customfor 4 hours

Sources & evidence

ORD record
ord-02b5ba5d389740dd8a35e615b00f10bb
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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